| Customization: | Available |
|---|---|
| Type: | Ivd Reagent |
| Transport Package: | Master Carton |
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FT3
Free Triiodothyronine (FT3) Kit (Chemiluminescence Immunoassay) is intended for in vitro quantitative determination of free triiodothyronine (FT3) content in human serum, based on NRM411 system.
Triiodothyronine is a hormone synthesized and secreted by thyroid or produced from its prohormone thyroxine (T4) outside thyroid. Roughly 80% of the circulating T3 is later formed in peripheral tissues by removal of the iodine atom from T4. In blood circulation, 99.7% of the T3 hormone reversibly binds to carrier proteins such as thyroxine-binding globulin (TBG), few albumins and prealbumins, and the rest T3 hormone remains in a free state. FT3 is the active form of hormone while the carrier protein bound T3 is not, thus the FT3 assay is meaningful to indicate thyroid function.
Clinical Significance
Thyroid dysfunction may cause excessive secretion of T3 and T4, and the level of FT3 in the body is related to the secretion and metabolism of T3. In patients with hypothyroidism and hyperthyroidism, the level of FT3 in the body changes along with level of total triiodothyronine.
Therefore, the determination of FT3 is an important index for routine clinical evaluation of thyroid function. The results can be used as the basis for the diagnosis of different thyroid diseases such as different types of hyperthyroidism and T3 thyrotoxicosis.
Test Principle
The assay is a competitive immunoassay for quantitative determination of FT3 concentration based on chemiluminescence immunoassay technology. The Magnetic Microbeads Reagent contains protecting reagents and magnetic microbeads that are coated with biotin labeled anti-T3 antibody. The Antibody Reagent contains the protecting reagents and acridinium ester labeled BSA-T3 conjugate.
Auxiliary Reagent contains protecting reagents. Sample, calibrator or control is mixed with Magnetic Microbeads Reagent, Antibody Reagent and Auxiliary Reagent to form a sandwich complex. After incubation and automatic magnetic separation conducted by the instrument, trigger solutions are added to generate chemiluminescent reaction and the relative light units (RLUs) are measured by a photomultiplier. A proportional relationship presents between the concentration of FT3 in the sample and the RLUs detected by the SUN306 system.
Packages
100 Tests/Box, 200 Tests/Box.
Storage and Stability
Sealed: Stable until the expiry date when stored at 2-8ºC.
Opened: Stable for 4 weeks for reagents. Stable for 1 week after dissolved/opened for solid control material/liquid control material. To ensure the kit's best performance, it is recommended to place opened kits in the refrigerator if it's not going to be used on board during the next 12 hours.
Do not use it beyond the expiration date.
Calibration and Traceability
Calibration
Each batch of kits contains specific calibration information, stored in the Calibration Card.
Traceability
The FT3 assay is traceable to a NIFDC standard reference material (lot No. 150550-201203).
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NO.
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Project name
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Abbreviation
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Method
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1
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Free thyroxine
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FT4
|
Magnetic particle chemiluminescence method
|
|
2
|
Total triiodothyronine
|
TT3
|
|
|
3
|
Total thyroxine
|
TT4
|
|
|
4
|
Thyroid Stimulating Hormone
|
TSH
|
|
|
5
|
Anti-thyroid peroxidase antibody
|
TPOAb
|
|
|
6
|
Antithyroglobulin antibody
|
TGAb
|
|
|
7
|
Free triiodothyronine
|
FT3
|
|
|
8
|
Thyroglobulin
|
TG
|
|
|
9
|
Prolactin
|
PRL
|
|
|
10
|
Estradiol
|
E2
|
|
|
11
|
Progesterone
|
P
|
|
|
12
|
Follicle Stimulating Hormone
|
FSH
|
|
|
13
|
Luteinizing hormone
|
LH
|
|
|
14
|
Creatine Kinase Isozyme
|
CK-MB
|
|
|
15
|
Myohemoglobin
|
MYo
|
|
|
16
|
TroponinI
|
cTnI
|
|
|
17
|
N-terminal pro-brain natriuretic peptide
|
NT-proBNP
|
|
|
18
|
|Laminin
|
LN
|
|
|
19
|
Type IV collagen
|
CIV
|
|
|
20
|
Type III procollagen N-terminal peptide
|
PIIINP
|
|
|
21
|
Hyaluronic acid
|
HA
|
|
|
22
|
Transferrin
|
FERRITIN
|
|
|
23
|
insulin
|
INS
|
|
|
24
|
C peptide
|
C-P
|
|
|
25
|
Procalcitonin
|
PCT
|
|
|
26
|
Alpha-fetoprotein
|
AFP
|
|
|
27
|
Carcinoembryonic antigen
|
CEA
|
|
|
28
|
Carbohydrate antigen 153
|
CA153
|
|
|
29
|
Carbohydrate antigen 199
|
CA199
|
|
|
30
|
Carbohydrate antigen 125
|
CA125
|
|
|
31
|
Free prostate specific antigen
|
f-PSA
|
|
|
32
|
Total prostate specific antigen
|
t-PSA
|
|
|
33
|
Growth hormone
|
GH
|
|
|
General reagents and consumables
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|||
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NO.
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Name
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Specification
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|
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1
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Cleaning fluid
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150ml/bottle
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|
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2
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substrate liquid
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100ml/bottle
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|
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3
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Sample Diluent 1
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25ml/bottle
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